Dose-response relationship between fasting plasma glucose and abnormal lung function in a health screening population
Complementary Medicine Research
|August 8, 2026
Summary
High fasting plasma glucose (FPG) is linked to abnormal lung function, especially in women and overweight individuals. Keeping FPG below 5.6 mmol/L may help prevent lung impairment.
Area of Science:
- Endocrinology
- Pulmonology
- Public Health
Background:
- Glucose metabolism and pulmonary health have complex, emerging links.
- The association between fasting plasma glucose (FPG) and lung function requires further characterization.
Purpose of the Study:
- To investigate the relationship between FPG and lung function abnormalities.
- To provide evidence on the dose-response nature of this association.
Main Methods:
- Cross-sectional analysis of 6,597 Chinese adults.
- Lung function categorized as normal or abnormal.
- Binary logistic regression and restricted cubic splines (RCS) used to model the FPG-lung function relationship, stratified by sex, age, and BMI.
Main Results:
- A significant non-linear dose-response relationship exists between FPG and lung function abnormalities.
- Increasing FPG from 4.78 to 5.6 mmol/L increased the risk of lung abnormalities by 32.0%.
- Women and overweight/obese individuals showed a steeper risk gradient.
Conclusions:
- FPG is an independent predictor of lung function abnormalities.
- Maintaining FPG below 5.6 mmol/L may prevent lung impairment.
- Early glycemic monitoring is crucial for predicting lung function.
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