[Lactose intolerance].

Area of Science:

• Gastroenterology
• Nutrition Science
• Biochemistry

Background:

• Lactose intolerance (LI) is a widespread issue hindering milk consumption.
• Primary lactase deficiency affects a significant portion of the global population, including 30% of Mexican adults.
• Secondary lactase deficiency arises from conditions impacting intestinal health.

Purpose of the Study:

• To summarize the causes and management of lactose intolerance.
• To explore the role of milk components, specifically beta-casein A1, in milk intolerance.

Main Methods:

• Literature review on lactose intolerance and milk intolerance.
• Analysis of studies investigating the effects of milk protein hydrolysis.

Main Results:

• Lactose intolerance symptoms are triggered by lactose intake, with primary lactase deficiency being a common cause.
• Milk intolerance symptoms can occur with or without lactose intolerance.
• Hydrolysis of beta-casein A1 in milk produces beta-casomorphin-7, an opioid linked to milk intolerance.

Conclusions:

• Lactose intolerance can be managed by reducing or eliminating milk and dairy product consumption.
• Beta-casomorphin-7, derived from beta-casein A1, is implicated as a potential factor in milk intolerance.