Related Experiment Video
Updated: Mar 15, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Globalization, Work, and Cardiovascular Disease
Peter L Schnall1, Marnie Dobson2, Paul Landsbergis3
1Center for Occupational and Environmental Health, University of California, Irvine, 100 Theory Way, Irvine, California, USA pschnall@workhealth.org.
Insights
Work environment stressors, like job demands and insecurity, contribute to cardiovascular disease (CVD) risk by causing chronic stress and unhealthy behaviors. Addressing these work-related factors is crucial for CVD prevention.
Area of Science:
- Epidemiology
- Occupational Health
- Social Determinants of Health
Background:
- Cardiovascular disease (CVD) remains a leading global cause of death, with increasing risk factors like hypertension and diabetes.
- While CVD mortality declines in industrialized nations, work environment factors, particularly psychosocial stressors, are linked to rising CVD risk.
Purpose of the Study:
- To review empirical evidence on the relationship between work, psychosocial stressors, and CVD.
- To present a theoretical model explaining how economic globalization impacts work organization and CVD risk.
- To propose future research directions and policy recommendations for preventing work-related CVD.
Main Methods:
- Systematic review of empirical studies linking work environment characteristics to CVD.
- Development of a theoretical model illustrating the pathway from economic globalization to CVD risk via work stressors.
- Analysis of "upstream" factors such as precarious employment and lean production.
Main Results:
- Psychosocial work stressors, including high demands, low job control, and effort-reward imbalance, are associated with increased CVD risk.
- These stressors can lead to chronic biological arousal and unhealthy behaviors, exacerbating CVD risk.
- Economic globalization influences labor markets, worsening job characteristics and contributing to CVD.
Conclusions:
- Work environment characteristics significantly contribute to the burden of cardiovascular disease.
- Policy interventions targeting work organization and job quality are needed for CVD prevention.
- Further epidemiologic research is essential to fully understand and mitigate work-related CVD.
Abstract:
Cardiovascular disease (CVD), a global epidemic, is responsible for about 30% of all deaths worldwide. While mortality rates from CVD have been mostly declining in the advanced industrialized nations, CVD risk factors, including hypertension, obesity, and diabetes, have been on the increase everywhere. Researchers investigating the social causes of CVD have produced a robust body of evidence documenting the relationships between the work environment and CVD, including through the mechanisms of psychosocial work stressors. We review the empirical evidence linking work, psychosocial stressors, and CVD. These work stressors can produce chronic biologic arousal and promote unhealthy behaviors and thus, increased CVD risk. We offer a theoretical model that illustrates how economic globalization influences the labor market and work organization in high-income countries, which, in turn, exacerbates job characteristics, such as demands, low job control, effort-reward imbalance, job insecurity, and long work hours. There is also a growing interest in "upstream" factors among work stress researchers, including precarious employment, downsizing/restructuring, privatization, and lean production. We conclude with suggestions for future epidemiologic research on the role of work in the development of CVD, as well as policy recommendations for prevention of work-related CVD.
More Related Videos
Related Concept Videos
Coronary Artery Disease I: Introduction
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
Coronary Artery Disease II: Pathophysiology
Cardiovascular Drugs: Classification based on Therapeutic Indications
Hypertension II: Pathophysiology

