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Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
Published on: January 7, 2019
Preliminary studies: differences in microRNA expression in asthma and chronic obstructive pulmonary disease
Małgorzata Pietrusińska1, Aneta Pająk1, Paweł Górski1
1Department of Pneumology and Allergology, Institute of Onternal Medicine, Medical University of Lodz, Lodz, Poland.
Introduction:
The asthma- and chronic obstructive pulmonary disease (COPD)-related morbidity has been increasing during the recent years. Both asthma and COPD are diseases of inflammatory etiology. The increasing interest in the pathomechanisms involved in the development of obstructive pulmonary diseases seems to be fully justified. Recent research has attempted to determine the associations of microRNA with the pathogenesis of pulmonary diseases.
Aim:
To assess the expression of microRNA in the blood sera of patients diagnosed with bronchial asthma and chronic obstructive pulmonary disease in comparison with healthy subjects.
Material And Methods:
In our study, at the preliminary stage, we compared the expression of miRNA in the groups of patients with asthma and COPD versus the control group of healthy subjects.
Results:
A significant difference in hsa-miRNA-224, hsa-miRNA-339-5p, hsa-miRNA-382 in patients with asthma and COPD as compared with the controls was noted.
Conclusions:
With such difference of expression of specific micro-RNA in serum of patient with asthma and COPD, those small non-coding RNA has to play a significant role in those diseases pathway. Therefore we expect to increase the size and differentation of the study groups in next studies.
Insights
Specific microRNAs (miRNAs) show altered expression in the blood serum of patients with asthma and chronic obstructive pulmonary disease (COPD). These findings suggest miRNAs play a role in the pathogenesis of these inflammatory lung diseases.
Area of Science:
- Pulmonary Medicine
- Molecular Biology
- Genetics
Background:
- Increasing global morbidity associated with asthma and chronic obstructive pulmonary disease (COPD).
- Both asthma and COPD are characterized by inflammatory processes.
- Emerging research highlights the role of microRNAs (miRNAs) in the pathogenesis of pulmonary diseases.
Purpose of the Study:
- To investigate and compare the expression levels of specific miRNAs in the blood sera of patients diagnosed with bronchial asthma and COPD.
- To establish a comparison between patient groups and healthy control subjects.
Main Methods:
- Preliminary analysis comparing miRNA expression profiles in serum samples.
- Inclusion of patient groups diagnosed with asthma and COPD.
- Comparison with a control group of healthy individuals.
Main Results:
- Significant differences in the expression of hsa-miRNA-224, hsa-miRNA-339-5p, and hsa-miRNA-382 were observed.
- These expression differences were noted when comparing patients with asthma and COPD to healthy controls.
Conclusions:
- The observed differential expression of specific miRNAs in serum suggests their significant involvement in the pathways of asthma and COPD.
- Further studies with larger and more differentiated patient cohorts are warranted to elucidate the precise role of these miRNAs.
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