Related Experiment Video
Updated: May 5, 2026
06:07
Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
Published on: June 13, 2020
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Postbiotics as Emerging Strategy Targeting Obesity- and Aging-Related Breast Cancer-Prospects in Prophylaxis and
Joanna Wasiak1,2, Katarzyna Anna Oszajca1, Janusz Szemraj1
1Department of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.
Life (Basel, Switzerland)
|May 4, 2026
Summary
Aging and obesity are linked to breast cancer risk. Postbiotics show promise in preventing and treating breast cancer by targeting aging and obesity-related cellular changes.
Area of Science:
- Oncology
- Gerontology
- Metabolism
Background:
- Aging and obesity are key risk factors for breast cancer, influencing its incidence, progression, and treatment outcomes.
- Hormonal imbalances associated with aging and obesity exacerbate breast cancer development.
- Current breast cancer therapies face challenges like acquired resistance and side effects, necessitating novel approaches.
Purpose of the Study:
- To explore the biological mechanisms connecting obesity and aging to breast cancer.
- To investigate the potential of postbiotics as therapeutic and preventive agents against breast cancer.
- To understand how postbiotics target cellular events crucial for cancer growth and treatment response.
Main Methods:
- This is a review article, synthesizing existing research on aging, obesity, breast cancer, and postbiotics.
- Mechanisms of postbiotic action on cellular events related to cancer growth and resistance were analyzed.
- The review focuses on the anti-neoplastic, antioxidant, anti-inflammatory, and anti-senescent properties of postbiotics.
Main Results:
- Postbiotics exhibit selective anti-cancer activity and cytoprotective effects.
- They possess antioxidant, anti-inflammatory, and anti-senescent properties beneficial in combating cancer.
- Postbiotics can counteract cellular disturbances linked to age- and obesity-related breast cancer development.
Conclusions:
- Postbiotics represent a promising strategy for breast cancer prevention and adjunctive therapy.
- Their pleiotropic effects address key factors in breast carcinogenesis and oncotherapy resistance.
- Further clinical studies are required to validate the efficacy and safety of postbiotics in routine cancer treatment.
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