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Related Concept Videos

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

119
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
119

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

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Patch Test Negative Generalized Dermatitis.

Alison Spiker1, Christen Mowad

  • 1From the Division of Dermatology, Geisinger Medical Center, Danville, PA.

Dermatitis : Contact, Atopic, Occupational, Drug
|September 9, 2016
PubMed
Summary
This summary is machine-generated.

Generalized dermatitis can be challenging to diagnose when patch testing is negative. This review outlines an approach for managing patients with widespread allergic contact dermatitis despite negative patch test results.

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Area of Science:

  • Dermatology
  • Allergology

Background:

  • Allergic contact dermatitis is a common dermatological condition.
  • Patch testing is the gold standard for diagnosing allergic contact dermatitis.
  • However, patch testing does not identify an allergen in all patients, and dermatitis is not always allergic.

Purpose of the Study:

  • To outline an approach for managing generalized dermatitis in patients who are negative on patch testing.
  • To summarize the limited literature available on patch test-negative generalized dermatitis.

Main Methods:

  • Literature review of existing studies on patch test-negative generalized dermatitis.
  • Clinical approach to diagnosis and management of challenging cases.

Main Results:

  • Generalized dermatitis affects more than 3 body sites.
  • Management of patch test-negative generalized dermatitis presents a clinical challenge.
  • There is a paucity of existing literature on this specific patient group.

Conclusions:

  • A systematic approach is needed to manage generalized dermatitis when patch testing is negative.
  • Further research is required to better understand and treat this condition.