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Can we use plasma hyperosmolality as a predictor of mortality for ST-segment elevation myocardial infarction?
Mustafa A Tatlisu1, Adnan Kaya, Muhammed Keskin
1aDepartment of Cardiovascular Science, Texas A&M Institute for Preclinical Science, College Station, Texas, USA bDepartment of Cardiology, Suruc State Hospital, Urfa cDepartment of Cardiology, Dr Siyami Ersek Cardiovascular Surgery Research and Training Hospital dDepartment of Family Medicine, Yenidogan Public Health Center, Istanbul, Turkey.
Background:
The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention.
Methods:
This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with STEMI treated with primary percutaneous coronary intervention. The following formula was used to measure the plasma osmolality at admission: osmolality=1.86×sodium (mmol/l)+glucose (mg/dl)/18+BUN (mg/dl)/2.8+9.
Results:
The patients were followed up for a mean period of 22±10 months. Patients with higher plasma osmolality had 3.7 times higher in-hospital (95% confidence interval: 2.7-5.1) and 3.2 times higher long-term (95% confidence interval: 2.5-4.1) all-cause mortality rates than patients with lower plasma osmolality.
Conclusion:
Plasma osmolality was found to be a predictor of both in-hospital and long-term all-cause mortality. Hence, plasma osmolality can be used to detect high-risk patients in STEMI.
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