Related Experiment Videos

Cardiovascular Diseases Risk Prediction by Homocysteine in Comparison to other Markers: A Study from Madhya Pradesh

Ashok Sahu1, Trapti Gupta2, Arvind Kavishwar3

  • 1Associate Professor.

The Journal of the Association of Physicians of India
|September 10, 2016
PubMed

Insights

Elevated homocysteine levels significantly predict cardiovascular disease risk, showing higher accuracy than other inflammatory markers. This finding highlights homocysteine as a crucial factor in atherosclerosis and vascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Inflammation Research

Background:

  • Atherosclerosis is linked to heightened inflammation and vascular disease risk.
  • The specific drivers of this inflammation remain unclear.
  • Understanding these factors is crucial for disease prevention and management.

Purpose of the Study:

  • To compare homocysteine levels with other cardiovascular disease risk markers.
  • To evaluate the predictive value of homocysteine in patients with atherosclerosis.
  • To identify key inflammatory factors associated with vascular disease.

Main Methods:

  • A study involving 200 participants, with 100 diagnosed cardiovascular disease patients and 100 controls.
  • Measurement of homocysteine, high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a), HbA1c, and blood lipids.
  • Collection of anthropometric and demographic data for comprehensive analysis.

Main Results:

  • Homocysteine and other measured markers were significantly elevated in patients with cardiovascular disease compared to the control group.
  • Homocysteine demonstrated a statistically significant increase in the diseased cohort.
  • Comparative analysis revealed distinct marker levels between patient and control groups.

Conclusions:

  • Homocysteine exhibits high sensitivity, specificity, and accuracy in identifying cardiovascular disease patients.
  • With an 89% positive predictive value and an odds ratio of 39.48, homocysteine is a potent predictor.
  • Homocysteine proves to be a more effective risk factor for cardiovascular disease than other evaluated markers.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
688
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.5K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
798
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
73
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
562
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
1.0K