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Updated: Mar 15, 2026

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Published on: June 23, 2023
The role of aquaporin-5 in cancer cell migration: A potential active participant
Helene H Jensen1, Frédéric H Login2, Jennifer S Koffman3
1Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Abstract:
Emerging data identifies the water channel aquaporin-5 as a major player in multiple cancers. Over-expression of aquaporin-5 has been associated with increased metastasis and poor prognosis, suggesting that aquaporin-5 may enhance cancer cell migration. This review aims to highlight the current knowledge and hypothesis regarding downstream signaling partners of aquaporin-5 in relation to cancer cell migration. The molecular mechanisms that link aquaporin-5 to cell migration are not completely understood. Aquaporin-5 may promote cell movement by increasing water uptake into the front of the cell allowing local swelling. Aquaporin-5 may also activate extracellular-regulated kinases, increasing proliferation and potentially stimulating the migration machinery. Thus, further studies are warranted to identify the underlying mechanisms and signaling pathways. This will reveal whether aquaporin-5 and downstream effectors could be targets for developing new cancer therapeutics.
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