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Granulomatous hypophysitis: a case of severe headache
Sharifah Faradila Wan Muhamad Hatta1, M Farhan Hamdan2, Siti Aishah Md Ali3
1Endocrine Unit, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
BMJ Case Reports
|September 11, 2016
Summary
Idiopathic granulomatous hypophysitis (GH) is a rare pituitary inflammation. This case study shows corticosteroids effectively treat GH, leading to symptom and imaging improvement.
Area of Science:
- Endocrinology
- Neurology
- Pathology
Background:
- Idiopathic granulomatous hypophysitis (GH) is an uncommon inflammatory pituitary disease.
- It impairs pituitary function due to immune cell infiltration.
Observation:
- A 39-year-old woman presented with headaches and blurred vision.
- MRI revealed a supra-sellar mass and pituitary stalk involvement.
- Hormonal tests indicated anterior pituitary deficiencies.
Findings:
- Histopathology confirmed hypophysitis.
- Glucocorticoid therapy led to immediate clinical and radiological remission.
- A steroid-sparing agent was added due to recurrence upon dose reduction.
Implications:
- GH has significant diagnostic and therapeutic implications.
- Medical treatment, particularly corticosteroids, can ameliorate clinical and radiological features.
- Increased recognition of GH can improve patient outcomes through timely intervention.
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