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Updated: Feb 10, 2026

Normothermic Machine Perfusion of Rat Kidneys for Transplantation
Published on: January 27, 2026
[History of kidney transplantation surgery]
M O Timsit1, F Kleinclauss2, R Thuret3
1Service d'urologie, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Paris, France.
Objectives:
To perform a state of the art about the history of kidney transplantation.
Material And Methods:
An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords (MESH): kidney transplantation, history, vascular anastomosis.
Results:
From the first vascular ligations to the discovery of ciclosporin, the history of organ transplantation was made of surgical bets and medical discoveries, such as blood group, HLA-system, immunity, etc. The audacity of some surgeons led to the onset of renal transplantation as the treatment of choice for end stage renal disease.
Conclusion:
This article aims to describe the first surgical methods for vascular anastomosis and renal transplantation. Through a comprehensive search within the archives of the French National Library, the authors provide a precise description of the first renal transplantations performed, the technique that have been used and their authors.
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