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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Targeted Cancer Therapies

Targeted Cancer Therapies

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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[Radiotherapy and targeted therapy/immunotherapy].

D Antoni¹, S Bockel², E Deutsch³

¹Département universitaire de radiothérapie, centre Paul-Strauss, UNICANCER, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France; EA 3430, fédération de médecine translationnelle de Strasbourg (FMTS), université de Strasbourg, 67200 Strasbourg, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique

|September 12, 2016

Summary

Recent advances in cancer treatments, including targeted therapies, immunotherapy, and stereotactic radiotherapy, improve patient outcomes. This review examines combining these therapies with radiotherapy for better cancer management.

Keywords:

Immunotherapy Immunothérapie Radiation therapy Radiothérapie Radiothérapie stéréotaxique Stereotactic radiotherapy Targeted therapies Thérapies ciblées

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Area of Science:

Oncology
Radiation Oncology
Medical Oncology

Background:

Systemic and local ablative treatments have significantly improved cancer care, enhancing local control and overall survival.
Innovations like targeted therapies, immunotherapy, and stereotactic radiotherapy have transformed patient management, particularly for oligometastatic disease.

Purpose of the Study:

To review the combination of radiotherapy with targeted therapy and immunotherapy.
To address the challenges and questions arising from these combined treatment modalities in oncology.

Main Methods:

Literature review of existing fundamental and clinical data.
Analysis of ongoing clinical trials and their potential impact on management protocols.

Main Results:

While fundamental data are available, clinical data on combined treatments remain limited.
New side effects and management strategies for combined therapies require further investigation.

Conclusions:

Ongoing trials are crucial for clarifying clinical management protocols for combined radiotherapy and targeted therapy/immunotherapy.
Further research is needed to fully understand the efficacy and safety of these combined treatment approaches in diverse primary tumor types.