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Copper Ion Binding Site in β-Amyloid Peptide.

Diana Yugay1,2, Dominic P Goronzy1,2, Lisa M Kawakami2

  • 1California NanoSystems Institute, University of California, Los Angeles , Los Angeles, California 90095, United States.

Nano Letters
|September 13, 2016
PubMed
Summary

Copper ions bind to specific histidine residues on beta-amyloid peptides, promoting the formation of beta-sheets crucial for Alzheimer's disease pathology. This binding site is key to understanding metal ion roles in neurodegeneration.

Keywords:
Alzheimer’s diseasebinding sitehistidine bracescanning tunneling microscopyβ-amyloidβ-sheet

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