Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

28.2K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
28.2K
Telomeres and Telomerase02:41

Telomeres and Telomerase

7.8K
7.8K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
Hematopoiesis01:21

Hematopoiesis

9.6K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.6K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microplastics and the Endocrine-Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid-Adipose Axis.

Environmental toxicology·2026
Same author

[Retropharyngeal Metastasis: A Rare and Frequently Aggressive Presentation of Papillary Thyroid Carcinoma].

Acta medica portuguesa·2026
Same author

Differentiating Upper Tract Urothelial Carcinoma with Synchronous or Metachronous Bladder Cancer.

Current issues in molecular biology·2026
Same author

Cutaneous diffuse large B-cell lymphoma induces a macrophage immunosuppressive phenotype through IL-10 secretion.

Blood advances·2025
Same author

CDKN2A homozygous deletions and TSC2 somatic mutations in metastatic pancreatic neuroendocrine tumors.

NPJ precision oncology·2025
Same author

Patient-derived tumoroids recapitulate the morphologic and molecular features of pediatric brain tumors.

NPJ precision oncology·2025

Related Experiment Video

Updated: Mar 15, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K

Telomerase Activation in Hematological Malignancies.

Joana Ropio1,2,3,4, Jean-Philippe Merlio5,6, Paula Soares7,8,9

  • 1Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France. joana.ropio@gmail.com.

Genes
|September 13, 2016
PubMed
Summary

Telomerase is crucial for cell survival and cancer, particularly in blood cancers. Understanding how the human telomerase reverse transcriptase gene (hTERT) is reactivated is key for developing new cancer diagnostics and therapies.

Keywords:
amplificationepigenetichematological malignancymutationpolymorphismtelomerase activityvirus

More Related Videos

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

8.7K
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

5.1K

Related Experiment Videos

Last Updated: Mar 15, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.8K
Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

8.7K
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

5.1K

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Telomere maintenance and telomerase expression are vital for cellular proliferation, survival, and development.
  • Dysregulation of telomerase is implicated in various cancers, including hematological malignancies.
  • The human telomerase reverse transcriptase (hTERT) gene is the rate-limiting subunit of telomerase.

Purpose of the Study:

  • To review the primary mechanisms governing telomerase activation.
  • To explore the link between telomerase reactivation and hematologic malignancies.
  • To highlight the significance of understanding hTERT regulation for clinical applications.

Main Methods:

  • Literature review of existing research on telomerase.
  • Analysis of transcriptional regulation mechanisms of hTERT.
  • Correlation of telomerase activation pathways with hematologic cancer development.

Main Results:

  • Telomerase activation involves complex transcriptional regulation of the hTERT gene.
  • Reactivation of telomerase is a common feature in many hematologic malignancies.
  • Specific mechanisms of hTERT regulation contribute to cancer progression.

Conclusions:

  • Understanding telomerase regulation is essential for advancing diagnostics and therapeutics in hematologic cancers.
  • Targeting telomerase reactivation pathways offers potential for novel cancer treatments.
  • Further research into hTERT regulation will illuminate its role in cancer biology.