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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
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Responsive self-assembled nanostructured lipid systems for drug delivery and diagnostics
Wye-Khay Fong1, Renata Negrini2, Jijo J Vallooran2
1Food and Soft Materials Science, Department of Health Science and Technology, ETH Zurich, Schmelzbergstrasse 9, CH-8092 Zurich, Switzerland; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Journal of Colloid and Interface Science
|September 14, 2016
Summary
Responsive lipid-based mesophase systems offer unique
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Stimuli-responsive polymers are widely studied.
- Responsive lipid-based mesophase systems present novel biomedical opportunities.
- These systems exhibit tunable nanostructures for dynamic control.
Purpose of the Study:
- To review the distinctive features of responsive lipid-based mesophase materials.
- To aggregate current research on their use in drug delivery and biosensing.
- To highlight their potential for 'on-demand' therapeutic delivery.
Main Methods:
- Review of existing literature and group research.
- Analysis of mesophase equilibrium structures and dynamic switching.
- Exploration of bulk gels and nanostructured dispersions.
Main Results:
- Responsive lipid-based mesophase systems enable controlled drug release.
- Dynamic nanostructure switching facilitates targeted delivery.
- These materials serve as transducers for biosensing applications.
Conclusions:
- Responsive lipid-based mesophase systems are versatile for biomedical applications.
- They offer advanced capabilities for drug delivery, biosensing, and diagnostics.
- Further research highlights their potential for 'on-demand' therapeutic strategies.
