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Characterization of Ovine Dermal Papilla Cell Aggregation
Agnes Rosarina Prita Sari1, Nicholas Wolfgang Rufaut2, Leslie Norman Jones2
1Department of Medicine, University of Melbourne, Parkville, Australia.
International Journal of Trichology
|September 15, 2016
Summary
Ovine dermal papilla (DP) cells maintain hair follicle-inducing activity and aggregative behavior in culture. Their stable molecular phenotype suggests potential for improving human cell-based hair growth therapies.
Area of Science:
- Dermatology
- Cell Biology
- Regenerative Medicine
Background:
- Dermal papilla (DP) cells are crucial for hair follicle formation and regeneration.
- Human DP cells lose hair-inducing capacity in culture, unlike ovine DP cells.
- Ovine DP cells retain aggregative behavior and hair growth potential, but their characteristics are not fully understood.
Purpose of the Study:
- To investigate the expression of known dermal papilla markers in ovine cells.
- To determine the association between marker expression and cell aggregation in ovine DP cells.
Main Methods:
- Ovine DP cells from three sheep were analyzed.
- Techniques included histochemistry, immunofluorescence, and polymerase chain reaction.
- 16 established DP markers were evaluated.
Main Results:
- All 16 evaluated DP markers were expressed in ovine DP aggregates.
- Versican (V0, V3), neural cell adhesion molecule, and corin expression increased with aggregation.
- Hey-1 expression decreased significantly with aggregation.
Conclusions:
- Aggregating ovine DP cells exhibit a stable phenotype similar to in vivo papillae.
- Phenotypic stability correlates with sustained hair follicle-inducing activity in culture.
- Ovine DP cells offer a promising model for enhancing human cell-based hair regeneration therapies.
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