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Acquired Perforating Disorder: A Case with Multiple Underlying Diseases
Agnes Rosarina Prita Sari1,2, Monika Puspitasari1,2, Hardyanto Soebono1,2
1Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
A man with itchy skin lumps had acquired perforating disorder. This skin condition is linked to chronic kidney disease, liver issues, and diabetes, highlighting the need for further research.
Area of Science:
- Dermatology and Venereology
- Pathology
Background:
- Acquired perforating disorder (APD) is a rare skin condition often misdiagnosed.
- APD is frequently associated with systemic diseases like chronic kidney disease (CKD), hepatic insufficiency, and diabetes mellitus.
Observation:
- A 51-year-old male patient presented with multiple pruritic papules.
- The patient had a history of end-stage renal disease requiring hemodialysis, hepatitis B, abnormal liver function, and hyperglycemia.
Findings:
- Histopathological examination revealed epidermal invagination with collagen extrusion, consistent with APD.
- The patient presented with all three common comorbidities associated with APD: CKD, liver disease, and diabetes.
Implications:
- This case underscores the importance of considering APD in patients with relevant comorbidities.
- Further research is warranted to understand the impact of multiple underlying diseases on APD severity.
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