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The relation of platelet-lymphocyte ratio and coronary collateral circulation in patients with non-ST segment
Serkan Akdag1, Aytac Akyol1, Muntecep Asker1
1Department of Cardiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Insights
High platelet-to-lymphocyte ratio (PLR) is linked to poor coronary collateral circulation (CCC) in non-ST elevation myocardial infarction (NSTEMI) patients. This finding highlights PLR as a potential indicator for assessing cardiovascular health in NSTEMI.
Area of Science:
- Cardiology
- Inflammation Markers
Background:
- Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory marker.
- PLR predicts adverse outcomes in cardiovascular disease.
Purpose of the Study:
- To investigate the association between PLR and coronary collateral circulation (CCC).
- Focus on patients with non-ST elevation myocardial infarction (NSTEMI).
Main Methods:
- Retrospective analysis of 386 NSTEMI patients undergoing coronary angiography.
- Patients categorized by CCC quality (poor vs. good) based on Rentrop grades.
- PLR calculated from complete blood count data.
Main Results:
- Significantly higher PLR in patients with poor CCC (153.9 ±26.6) compared to good CCC (129.8 ±23.5).
- PLR identified as an independent predictor of poor CCC (OR: 1.51, p < 0.001).
- ROC analysis indicated a PLR cutoff of 140.5 for predicting poor CCC with 79% sensitivity and 71% specificity.
Conclusions:
- Elevated PLR is independently associated with poor coronary collateral circulation in NSTEMI.
- PLR may serve as a valuable biomarker for assessing collateralization in NSTEMI.
Introduction:
Recently, platelet-to-lymphocyte ratio (PLR) has emerged as a significant inflammatory marker and a novel predictor of major adverse consequences in cardiovascular disease.
Aim:
In this study, we aimed to explore the relationship between PLR and coronary collateral circulation (CCC) in patients with non-ST elevation myocardial infarction (NSTEMI).
Material And Methods:
Clinical and laboratory data of 386 patients who underwent coronary angiography were evaluated retrospectively. The patients were classified into 2 groups as follows: poor CCC (group 1: Rentrop grades 0-1) and good CCC (group 2: Rentrop grades 2-3). The PLR was calculated from the complete blood count.
Results:
The PLR values of the patients with poor CCC were significantly higher than those of patients with good CCC (153.9 ±26.6 vs. 129.8 ±23.5, p < 0.001). In the multiple logistic regression tests, PLR (odds ratio: 1.51, 95% confidence interval: 1.27-1.74; p < 0.001) and hs-CRP (odds ratio: 1.56, 95% CI: 1.03-2.11; p < 0.001) were found to be independent predictors of poor CCC. The receiver operating characteristic (ROC) curve analysis yielded a cutoff value of 140.5 for PLR to predict poor CCC with 79% sensitivity and 71% specificity, with the area under the ROC curve being 0.792 (95% CI: 0.721-0.864).
Conclusions:
Our study revealed that high PLR is independently associated with poor coronary collateral circulation in patients with NSTEMI.
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