Longitudinal study using voxel-based relaxometry: Association between cartilage T_1ρ and T₂ and patient reported...

To study the local distribution of hip cartilage T_1ρ and T₂ relaxation times and their association with changes in patient reported outcome measures (PROMs) using a fully automatic, local, and unbiased method in subjects with and without hip osteoarthritis (OA).

The 3 Tesla MRI studies of the hip were obtained for 37 healthy controls and 16 subjects with radiographic hip OA. The imaging protocol included a three-dimensional (3D) SPGR sequence and a combined 3D T_1ρ and T₂ sequence. Quantitative cartilage analysis was compared between a traditional region of interest (ROI)-based method and a fully automatic voxel-based relaxometry (VBR) method. Additionally, VBR was used to assess local T_1ρ and T₂ differences between subjects with and without OA, and to evaluate the association between T_1ρ and T₂ and 18-month changes PROMs.

Results for the two methods were consistent in the acetabular (R = 0.79; coefficients of variation [CV] = 2.9%) and femoral cartilage (R = 0.90; CV = 2.6%). VBR revealed local patterns of T_1ρ and T₂ elevation in OA subjects, particularly in the posterosuperior acetabular cartilage (T_1ρ : P = 0.02; T₂ : P = 0.038). Overall, higher T_1ρ and T₂ values at baseline, particularly in the anterosuperior acetabular cartilage (T_1ρ : Rho = -0.42; P = 0.002; T₂ : Rho = -0.44; P = 0.002), were associated with worsening PROMS at 18-month follow-up.

VBR is an accurate and robust method for quantitative MRI analysis in hip cartilage. VBR showed the capability to detect local variations in T_1ρ and T₂ values in subjects with and without osteoarthritis, and voxel based correlations demonstrated a regional dependence between baseline T_1ρ and T₂ values and changes in PROMs.

1 J. MAGN. RESON. IMAGING 2017;45:1523-1533.