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TGFB1 Gene Promoter Polymorphisms in Serbian Asthmatics
Sandra Dragicevic1, Natasa Petrovic-Stanojevic2, Aleksandra Nikolic1
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia.
Summary
The TGFB1 C-509T gene variant may be linked to asthma and its exacerbations in Serbian patients. The G-800A variant showed no significant association with asthma development or severity.
Area of Science:
- Genetics
- Respiratory Medicine
- Immunology
Background:
- Asthma is a chronic respiratory disease influenced by genetic and environmental factors.
- Transforming growth factor beta 1 (TGFB1) is a key cytokine in asthma-related airway remodeling.
Purpose of the Study:
- To investigate the association of TGFB1 gene promoter polymorphisms C-509T and G-800A with asthma in a Serbian population.
- To determine if these polymorphisms correlate with asthma exacerbations.
Main Methods:
- Study included 102 asthmatics and 58 healthy controls from Serbia.
- TGFB1 promoter polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Main Results:
- A significant difference in allele frequency for the TGFB1 C-509T polymorphism was found between asthmatic patients and controls (p=0.011).
- The -509TT genotype was more frequent in patients experiencing asthma exacerbations (36.4%) compared to those without (17.0%), nearing statistical significance (p=0.080).
- No significant association was observed for the TGFB1 G-800A polymorphism in relation to asthma or exacerbations.
Conclusions:
- The TGFB1 C-509T polymorphism suggests a potential role in asthma susceptibility and exacerbations.
- The TGFB1 G-800A polymorphism does not appear to be significantly associated with the etiology or clinical course of asthma.
- Further validation in larger cohorts and consideration of environmental factors are recommended for comprehensive understanding.
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