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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Spectrally encoded common-path fiber-optic-based parallel optical coherence tomography.

Kye-Sung Lee, Hwan Hur, Ha-Young Sung

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    This summary is machine-generated.

    We developed a novel fiber-optic parallel optical coherence tomography (OCT) system using a common-path handheld probe. This robust system achieves high sensitivity and phase stability, enabling detailed in vivo imaging of human skin.

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    Area of Science:

    • Biomedical Optics
    • Optical Engineering
    • Medical Imaging

    Background:

    • Optical Coherence Tomography (OCT) is a crucial imaging modality.
    • Existing OCT systems can lack flexibility and robustness for clinical use.
    • Fiber-optic integration offers potential for improved OCT system design.

    Purpose of the Study:

    • To develop and demonstrate a fiber-optic-based parallel OCT system.
    • To enhance system flexibility, robustness, and clinical applicability.
    • To evaluate the phase stability and imaging performance of the novel system.

    Main Methods:

    • Spectrally encoded extended illumination with a common-path handheld probe.
    • Integration of a fiber coupler for parallel OCT signal acquisition.
    • Comparison of common-path OCT with two-arm OCT for phase stability analysis.
    • In vivo imaging of human skin for performance demonstration.

    Main Results:

    • Demonstrated the first fiber-optic parallel OCT system with a 94 dB sensitivity.
    • Achieved 32 times better phase stability compared to two-arm OCT using a Mirau interferometer.
    • Measured an axial resolution of 5.1±0.3 μm.
    • Successfully imaged human skin in vivo.

    Conclusions:

    • The fiber-optic parallel OCT system offers significant improvements in flexibility and robustness.
    • The common-path design enhances phase stability, crucial for clinical applications.
    • This technology shows promise for advanced in vivo biomedical imaging.