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Proteinuria can predict prognosis after liver transplantation
Heng-Chih Pan1, Ying-Jen Chen2, Jhe-Ping Lin3
1Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
BMC Surgery
|September 16, 2016
Summary
Proteinuria before and after liver transplantation indicates poor prognosis. Detecting proteinuria aids in early prediction of adverse outcomes for transplant patients, improving survival prediction.
Area of Science:
- Nephrology
- Transplant Surgery
- Critical Care Medicine
Background:
- Proteinuria signifies renal dysfunction and is a key prognostic indicator.
- This study investigates the prognostic value of perioperative proteinuria in liver transplant recipients.
- Understanding proteinuria's role can enhance patient outcomes.
Observation:
- A retrospective review of 323 liver transplant patients (2002-2010) was conducted.
- Data included demographics and clinical parameters pre- and post-transplant.
- Perioperative proteinuria was assessed on admission and postoperative days 1, 7, and 14.
Findings:
- Patients with proteinuria showed higher rates of acute kidney injury, severe infections, and mortality (in-hospital and 90-day).
- Proteinuria on admission and SOFA score independently predicted in-hospital mortality.
- Proteinuria combined with SOFA score improved mortality prediction, particularly on postoperative day 1.
Implications:
- Pre-transplant proteinuria is a negative predictor of in-hospital survival.
- Post-transplant proteinuria aids in early identification of patients with poor short-term prognosis.
- Integrating proteinuria assessment can refine risk stratification in liver transplant care.
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