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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

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A RESCUE THERAPY FOR PERSISTENT OPTIC DISK PIT MACULOPATHY IN PREVIOUSLY VITRECTOMIZED EYES.

Marta S Figueroa^1,2, Jeroni Nadal³, Inés Contreras^1,4

¹Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRICYS), Madrid, Spain.

Retinal Cases & Brief Reports

|September 16, 2016

Summary

Vitrectomy with platelet-rich plasma (PRP) application offers a promising rescue therapy for persistent optic disk pit (ODP) maculopathy. This treatment effectively resolved maculopathy in all patients, preventing recurrences over three years.

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Area of Science:

Ophthalmology
Regenerative Medicine

Background:

Optic disk pit (ODP) maculopathy can cause visual loss, particularly in eyes with prior vitrectomies.
Refractory ODP maculopathy presents a significant clinical challenge, often requiring novel therapeutic approaches.

Observation:

This study evaluated vitrectomy combined with platelet-rich plasma (PRP) application and gas tamponade as a rescue therapy.
Three patients with persistent or recurrent ODP maculopathy after previous vitrectomy were treated with PRP.

Findings:

Maculopathy improved within two weeks and resolved in all treated eyes between six and eight months.
No recurrences were observed during a three-year follow-up period.
Visual acuity improved in two eyes and remained stable in one eye.

Implications:

Vitrectomy with PRP application shows potential as an effective rescue therapy for refractory ODP maculopathy.
PRP may facilitate closure of the vitreous-macular/subretinal communication at the optic disk pit.
This approach may offer a safer alternative to existing treatments for ODP maculopathy.