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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Variable density magnetization transfer (vdMT) imaging for 7T MR imaging.

Se-Hong Oh1, Wanyong Shin2, Jongho Lee3

  • 1Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA; Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Republic of Korea.

Neuroimage
|September 17, 2016
PubMed
Summary
This summary is machine-generated.

A new variable density magnetization transfer (vdMT) imaging technique enables high-resolution brain scans at ultra-high field (UHF) 7T MRI. This method significantly reduces scan time and specific absorption rate (SAR), making it suitable for neurological disease patients.

Keywords:
7TMTMTRMagnetization transfer imagingMagnetization transfer ratioUHFUltra-high fieldVariable density MT

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Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging (MRI)
  • Biophysics

Background:

  • Ultra-high field (UHF; ≥7T) MRI offers enhanced resolution but faces challenges with high specific absorption rate (SAR) and prolonged scan times for conventional Magnetization Transfer (MT) imaging.
  • Magnetization Transfer Ratio (MTR) is sensitive to myelin concentration changes, crucial for detecting neurological damage, but its application in UHF in-vivo studies is limited.
  • Existing pulsed MT sequences at UHF are not well-suited for routine clinical use due to SAR and time constraints.

Purpose of the Study:

  • To introduce and validate a novel variable density Magnetization Transfer (vdMT) imaging approach for 7T MRI systems.
  • To reduce scan time and SAR while maintaining high-resolution MTR image quality comparable to conventional MT methods.
  • To assess the feasibility of vdMT for routine patient scans in neurological disease diagnostics.

Main Methods:

  • Developed a vdMT imaging sequence applying a higher density of MT RF pulses in the center of k-space and sparse application in the outer regions.
  • Optimized the fraction of k-space with 100% MT RF density and repetition time (TR) using in-vivo region of interest (ROI) analysis.
  • Acquired high-resolution MTR maps using vdMT in healthy controls and patients with multiple sclerosis (MS), including postmortem MS brain analysis.

Main Results:

  • vdMT imaging successfully covered the whole brain volume within an acceptable scan time for routine patient examinations.
  • MTR image quality from vdMT was comparable to conventional MT imaging, with high correlation coefficients (0.95 in phantom, 0.90 in postmortem MS brain, 0.85 in healthy volunteers).
  • Signal reductions in MTR maps correlated with MS lesions in both postmortem and in-vivo MS patient data.

Conclusions:

  • The vdMT approach provides a new method for acquiring high-resolution whole-brain MTR maps at 7T MRI.
  • vdMT significantly shortens scan time and reduces SAR compared to conventional MT imaging, enhancing patient comfort and applicability.
  • This vdMT technique is a promising tool for UHF MRI in patients with neurological diseases, offering diagnostic potential.