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Updated: Mar 15, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Preparations, characterization, and biological features of mononuclear Cu(II) complexes based on hydrazone ligands
Jie Qin1, Shan-Shan Zhao1, Ya-Ping Liu1
1School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China.
Abstract:
Three mononuclear Cu(II) complexes Cu(HL1)Cl2 (1), Cu(HL2)Cl2 (2), and Cu(L3)SCN (3) have been synthesized based on chelating hydrazone ligands HL1, HL2, and HL3, respectively. These new compounds gave satisfactory IR-spectroscopic data and were further characterized by elemental and X-ray diffraction analyses. Their urease inhibitory evaluation was tested in vitro against jack bean urease. The results showed that the inhibitory activities of the copper complexes are all superior to the positive reference. Enzyme kinetics studies were undertaken to estimate the inhibition mechanism of the copper complexes. Molecular docking simulations have been performed to rationalize their binding models. In addition, their interactions with serum albumin were also studied.
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