[Thrombocyte aggregation and the secretion reaction in hemophilia patients]

The action of platelet aggregation and release reaction on the tendency toward bleeding in patients with hemophilia was studied. Were examined 43 patients with hemophilia A, 14 of them with hemorrhages, 5 patients with hemophilia B, 5 patients with hemophilia A and factor VIII inhibitor and 2 patients with congenital factor VII deficit. Disturbed aggregation with ADP was found in 2 patients and with adrenalin also in 2 patients with hemophilia A without hemorrhages, in 1 patient with hemophilia A with hemorrhages and in 1 patient with hemophilia B. In the remaining patients the examined indices were normal. No data for spontaneous aggregation were found. The results of the study indicate that no connection was established between the tendency toward bleeding in the hemophiliac patients and the platelet aggregation and release reaction. No data for platelet hyperactivation by the hemorrhages were found.