Intravesical silver nitrate for refractory hemorrhagic cystitis.

Area of Science:

• Urology
• Oncology

Background:

• Hemorrhagic cystitis (HC) is a difficult condition with limited treatment evidence.
• Intravesical silver nitrate is a reported treatment, but literature is sparse.

Purpose of the Study:

• To assess the outcomes of intravesical silver nitrate for refractory hemorrhagic cystitis.

Main Methods:

• Nine patients with refractory HC received intravesical silver nitrate.
• All patients had failed prior continuous bladder irrigation and clot evacuation.
• Treatment success was defined as no additional therapy needed post-instillation.

Main Results:

• The median patient age was 80 years; 89% of cases were radiation-induced.
• Patients received varying doses of silver nitrate, some under anesthesia.
• 100% of patients had persistent hematuria, requiring transfusions and further interventions.

Conclusions:

• Intravesical silver nitrate was well-tolerated but ineffective for bleeding control in HC.
• The agent has a limited role in managing hemorrhagic cystitis.