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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Prevalence and risk factors for left ventricular diastolic dysfunction in a scleroderma cohort
S Vemulapalli1, L Cohen2, V Hsu3
1a Graduate School of Biomedical Sciences , Rutgers University , New Brunswick , NJ , USA.
Scandinavian Journal of Rheumatology
|September 17, 2016
Summary
Left ventricular diastolic dysfunction (LVDD) is common in systemic sclerosis (SSc). Advanced age, hypertension, and lung complications are key risk factors for LVDD in SSc patients, who also face higher mortality rates.
Area of Science:
- Cardiology
- Rheumatology
- Pulmonology
Background:
- Left ventricular diastolic dysfunction (LVDD) is more prevalent in systemic sclerosis (SSc) patients.
- Myocardial ischemia and fibrosis may contribute to LVDD pathogenesis in SSc.
- LVDD is linked to increased mortality, but risk factors remain unclear.
Purpose of the Study:
- To identify clinical factors associated with LVDD in SSc patients.
- To investigate the relationship between LVDD and SSc complications.
- To determine risk factors for LVDD in systemic sclerosis.
Main Methods:
- Cross-sectional study of 300 SSc outpatients.
- Echocardiography (tissue Doppler imaging) for LVDD diagnosis.
- Regression analyses to identify clinical factors associated with LVDD.
Main Results:
- 133 (44%) SSc patients had LVDD.
- Multivariate analysis identified advanced age, systemic hypertension, and SSc lung complications as significant factors associated with LVDD.
- LVDD group had significantly higher mortality.
Conclusions:
- LVDD is prevalent in SSc, particularly with advanced age, hypertension, or pulmonary complications.
- Pulmonary fibrosis and hypertension in SSc patients correlate with advanced LVDD and increased mortality.
- Improved therapies are needed for SSc patients with LVDD.
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