Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A radiation overdose incident: initial data

L Cohen1, T E Schultheiss, R C Kennaugh

  • 1Department of Radiation Oncology, University of Chicago, IL 60637, USA.

International Journal of Radiation Oncology, Biology, Physics
|August 30, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD14-independent responses to LPS require a serum factor that is absent from neonates.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same author

T cell receptor repertoire in the peripheral blood and intestinal mucosa of coeliac patients.

Clinical and experimental immunology·1995
Same author

Suramin and hydrocortisone: determining drug efficacy in androgen-independent prostate cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1995
Same author

Body dysmorphic disorder in the DSM-IV field trial for obsessive-compulsive disorder.

The American journal of psychiatry·1995
Same author

Seasonal rhythm of platelet [3H]imipramine binding in adolescents who attempted suicide.

The American journal of psychiatry·1995
Same author

Neutron irradiation of human pelvic tissues yields a steep dose-response function for late sequelae.

International journal of radiation oncology, biology, physics·1995
Same journal

Local sinonasal and regional nodal effects of lymph node irradiation in a pilot study of dogs with naturally occurring sinonasal tumors.

International journal of radiation oncology, biology, physics·2026
Same journal

Cross-Institutional Validation of a novel LLM-Based Cardiac Event Extraction framework from Electronic Health Records.

International journal of radiation oncology, biology, physics·2026
Same journal

Cardiac Substructure Dosimetry and Major Adverse Cardiac Events After Breast Radiotherapy: A 12-Year Cohort Study with NTCP Modeling.

International journal of radiation oncology, biology, physics·2026
Same journal

Predictors of Medical Debt Sent to Collections after Radiotherapy.

International journal of radiation oncology, biology, physics·2026
Same journal

External Beam Radiotherapy Primes PDL1-Targeted Radionuclide Therapy in Preclinical Colorectal Cancer Model.

International journal of radiation oncology, biology, physics·2026
Same journal

Radiobiological characterization of 60 keV quasi-monoenergetic convergent photons.

International journal of radiation oncology, biology, physics·2026
See all related articles

This study evaluated severe complications in 426 patients receiving high-dose radiation therapy. Results show 34% experienced immediate severe complications, highlighting the need for precise radiation dose limits for human tissues.

Area of Science:

  • Radiation oncology
  • Radiobiology
  • Medical physics

Background:

  • Accurate radiation dose limits are crucial for minimizing severe complications in patients undergoing radiotherapy.
  • Understanding tissue tolerance to radiation is essential for optimizing treatment planning and improving patient outcomes.

Purpose of the Study:

  • To estimate tolerance limits for human tissues by analyzing reactions in patients who received radiation overdoses.
  • To evaluate complication rates and derive dose-response functions from a unique patient cohort.

Main Methods:

  • Analysis of a data file containing technical and dosimetric information from 426 patients.
  • Utilizing hierarchical coding protocols for region, system, and organ analysis.
  • Evaluating 795 discrete irradiated tissues across multiple organs.

Related Experiment Videos

Main Results:

  • In 183 long-term survivors (beyond 1 year), 62 patients (34%) experienced severe complications.
  • Complications were observed in irradiated sites including brain, spinal cord, skin, oropharyngeal mucosa, colon, and rectum.
  • The study analyzed responses to high doses and unusual fractionation beyond conventional clinical experience.

Conclusions:

  • The dataset provides a valuable resource for estimating human tissue tolerance limits.
  • This data can be used for testing radiobiological models and developing new optimization algorithms in radiation therapy.
  • Findings underscore the importance of precise dose calibration and adherence to established tolerance limits.