Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

1.1K
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
1.1K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.9K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.9K
Storage01:23

Storage

476
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
476

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Complexity of Pediatric Hemophagocytic Lymphohistiocytosis With Central Nervous System Involvement.

Pediatric neurology·2026
Same author

Clinical Impact of Maximum Plasma Concentration of Busulfan in Pediatric Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation.

Clinical pharmacology and therapeutics·2026
Same author

Lightning Pose 3D: an uncertainty-aware framework for data-efficient multi-view animal pose estimation.

bioRxiv : the preprint server for biology·2026
Same author

Discovery of Casdatifan, Part I: Design and Characterization of Tetrahydroquinoline Inhibitors of Hypoxia-Inducible Factor-2α.

Journal of medicinal chemistry·2026
Same author

Population Pharmacokinetics of Melphalan in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation with Various Conditioning Regimens.

European journal of drug metabolism and pharmacokinetics·2026
Same author

Cooling immunochemotherapy and hematopoietic stem cell transplantation for refractory systemic epstein-barr virus-positive T-cell lymphoma in children: a single institution experience.

Annals of hematology·2026

Related Experiment Video

Updated: Mar 15, 2026

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

1.8K

Dissociated sequential activity and stimulus encoding in the dorsomedial striatum during spatial working memory.

Hessameddin Akhlaghpour1, Joost Wiskerke1,2, Jung Yoon Choi1,2

  • 1Princeton Neuroscience Institute, Princeton University, Princeton, United States.

Elife
|September 17, 2016
PubMed
Summary

Neural activity in the striatum shows sequential activation during extended delays in spatial working memory tasks. This sequential firing is separate from stimulus encoding, clarifying the striatum's role.

Keywords:
electrophysiologyneuroscienceratstriatumworking memory

More Related Videos

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

12.9K
A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

14.2K

Related Experiment Videos

Last Updated: Mar 15, 2026

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

1.8K
An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

12.9K
A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

14.2K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • The striatum is implicated in spatial working memory.
  • Neural dynamics in the striatum are understood for short delays (1-4s) but not long delays.
  • Understanding striatal function during extended delays is crucial for a complete picture of working memory.

Purpose of the Study:

  • To investigate neural dynamics in the dorsomedial striatum during spatial working memory tasks with long delay periods (up to 10s).
  • To characterize the nature of neuronal activation and its relationship to stimulus encoding during extended delays.

Main Methods:

  • Single unit recordings were obtained from the dorsomedial striatum of rats.
  • Rats performed a spatial working memory task with varying delay periods up to 10 seconds.
  • Neuronal activity was analyzed to identify patterns of activation and their temporal relationship to task events.

Main Results:

  • Neurons in the dorsomedial striatum exhibited sequential activation patterns that spanned the entire duration of the extended delay period.
  • This sequential activity was found to be distinct from stimulus encoding activity.
  • Stimulus encoding activity was observed but was concentrated towards the beginning of the delay period.

Conclusions:

  • The striatum utilizes sequential neural dynamics to support spatial working memory over extended delays.
  • These dynamics are dissociable from initial stimulus encoding, suggesting distinct neural mechanisms within the striatum for different phases of working memory.
  • Findings provide novel insights into the role of the striatum in cognitive functions requiring temporal information processing.