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[Detoxifying function of the liver in patients with rubromycosis during treatment with antimycotics]

I Z Lapina, V M Leshchenko, E A Bendikov

    Vestnik Dermatologii I Venerologii
    |January 1, 1989
    PubMed

    Insights

    Oral antifungal drugs like nizoral and griseofulvin can affect liver enzyme activity, specifically cytochrome P450. This impacts how the body processes other medications, as shown by changes in antipyrine metabolism.

    Area of Science:

    • Pharmacology
    • Hepatology
    • Drug Metabolism

    Background:

    • Oral antifungal agents, including nizoral and griseofulvin, are frequently prescribed.
    • These drugs are known to interact with hepatic enzyme systems.
    • The cytochrome P450 system is crucial for drug metabolism in the liver.

    Purpose of the Study:

    • To investigate the impact of oral nizoral and griseofulvin on liver cytochrome P450-dependent monoxygenases.
    • To determine the effect of these antifungals on antipyrine microsomal oxidation.
    • To provide guidance on interpreting antipyrine test results during antifungal therapy.

    Main Methods:

    • Administration of oral nizoral and griseofulvin to subjects.
    • Measurement of liver microsomal oxidation of antipyrine.
    • Analysis of changes in enzyme activity.

    Main Results:

    • Oral nizoral and griseofulvin therapy led to a significant depression of antipyrine microsomal oxidation.
    • This indicates an influence on the cytochrome P450 system by these antifungal drugs.
    • Altered drug metabolism was observed during treatment.

    Conclusions:

    • Nizoral and griseofulvin alter hepatic cytochrome P450 activity.
    • Antipyrine metabolism is depressed by these oral antifungal medications.
    • Clinical recommendations for managing antipyrine test data during such therapies are necessary.

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