Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K

Maternal Circulating microRNAs and Pre-Eclampsia: Challenges for Diagnostic Potential.

Malia S Q Murphy1, Chandrakant Tayade1, Graeme N Smith2,3

  • 1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

Molecular Diagnosis & Therapy
|September 18, 2016
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A message from the new CSCI President, Dr. Chandrakant Tayade.

Clinical and investigative medicine. Medecine clinique et experimentale·2026
Same author

Implementation Strategies: Bridging Obstetrics and Long-Term Care.

American journal of obstetrics & gynecology MFM·2026
Same author

Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Correction: Misregulated alternative splicing in endometriosis: a role for aberrant mRNA variants in endometriotic cell growth.

Cell death discovery·2026
Same author

Development and Validation of a Prediction Model for Cardiovascular Risk in Reproductive-Aged Women.

JACC. Advances·2026
Same author

Immune dysregulation in endometriosis: the T cell perspective.

Frontiers in immunology·2026

Pre-eclampsia (PE) is a pregnancy disorder impacting mothers and newborns. Researchers are exploring circulating microRNAs (miRNAs) as potential biomarkers for predicting and diagnosing PE, offering a less invasive approach.

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Pre-eclampsia (PE) is a significant hypertensive disorder in pregnancy.
  • It contributes substantially to maternal and neonatal mortality and morbidity.
  • Current diagnostic and predictive biomarkers for PE lack robust utility.

Purpose of the Study:

  • To review the current knowledge on microRNAs (miRNAs) associated with pre-eclampsia.
  • To explore the potential of circulating miRNAs as biomarkers for PE.
  • To discuss challenges in developing miRNAs for clinical use in PE.

Main Methods:

  • This article presents a narrative review of existing literature.
  • It focuses on studies investigating circulating miRNAs in pre-eclampsia.

More Related Videos

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.3K
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

612

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.3K
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

612
  • The review synthesizes findings on miRNA profiles and their association with PE.

    • Main Results:

    • Limited literature currently exists on the circulating miRNAome of pre-eclampsia.
    • microRNAs (miRNAs) are stable in plasma, making them attractive candidates for biomarkers.
    • Further research is needed to establish the diagnostic and prognostic value of miRNAs in PE.

    Conclusions:

    • Circulating miRNAs show promise as potential biomarkers for pre-eclampsia.
    • Challenges remain in validating their utility for diagnosis and prognosis.
    • Developing miRNA-based diagnostics could improve management of PE.