Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing

Area of Science:

• Neuroscience
• Biomaterials Engineering
• Medical Devices

Background:

• Traditional neural stimulation systems use metal microelectrodes, causing tissue damage and long-term instability.
• Existing technologies face limitations in electrochemical properties, hindering efficient and stable neural interfacing.

Purpose of the Study:

• To develop a flexible cortical microelectrode array using porous graphene for minimally invasive neural sensing and stimulation.
• To evaluate the electrochemical properties, durability, and in vivo performance of the porous graphene electrodes.

Main Methods:

• Fabrication of a flexible cortical microelectrode array utilizing porous graphene.
• Characterization of electrode impedance and charge injection capabilities.
• In vivo testing in rodents for neural activity sensing and muscle stimulation.

Main Results:

• Porous graphene electrodes demonstrated superior impedance and charge injection compared to traditional electrodes.
• The array showed high endurance, withstanding over 1 million stimulation cycles without degradation.
• Successful in vivo demonstration of high-resolution neural sensing and precise muscle stimulation from the cortical surface.

Conclusions:

• Flexible porous graphene arrays offer a minimally invasive, high-efficiency alternative for neural sensing and stimulation.
• These arrays show significant potential for applications in cortical mapping, brain-computer interfaces, and neurological disorder treatments.
• The technology provides a stable and durable platform for advanced neuromodulation strategies.