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Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
Synne Jenum1, Sivakumaran Dhanasekaran, Christian Ritz
1From the *Department of Clinical Science, University of Bergen, Bergen, Norway; †Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway; ‡Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway; §Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; ¶Division of Infectious Diseases, St. John's Research Institute, Koramangala, Bangalore, India; and ‖GlaxoSmithKline, Vaccines, Wavre, Belgium.
Abstract:
We have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.
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