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Related Experiment Videos

Hypersensitivity angiitis associated with naproxen.

P C Singhal1, M Faulkner, J Venkatesan

  • 1Division of Nephrology, Queens Hospital Ctr., Jamaica, NY 11432.

Annals of Allergy
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

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Naproxen can cause severe kidney damage, including vasculitis and renal failure, particularly in individuals with elevated IgE. Prompt discontinuation of the drug led to symptom resolution and improved kidney function in a patient case.

Area of Science:

  • Nephrology
  • Immunology
  • Dermatology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen are commonly prescribed.
  • NSAID-induced nephrotoxicity can manifest in various forms.
  • Elevated immunoglobulin E (IgE) levels may be associated with specific adverse drug reactions.

Observation:

  • A 52-year-old male presented with cutaneous necrotizing vasculitis, acute kidney injury, and massive proteinuria.
  • The patient had significantly elevated serum IgE levels.
  • Symptoms emerged after initiating oral naproxen therapy.

Findings:

  • Renal biopsy showed cellular crescents in over 40% of glomeruli, indicative of severe glomerular injury.
  • Arteriolar changes included intimal thickening and eosinophilia.

Related Experiment Videos

  • Electron microscopy revealed diffuse podocyte foot process effacement.

    • Implications:

    • This case highlights naproxen as a potential cause of IgE-mediated hypersensitivity vasculitis with severe renal involvement.
    • Early recognition and withdrawal of naproxen are crucial for managing NSAID-induced nephrotoxicity.
    • Further research into the mechanisms of NSAID-associated glomerular and vascular injury is warranted.