Related Experiment Video
Updated: Mar 14, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Autophagic regulation in steroid hormone-responsive systems
Jaekyoung Park1, Hyejin Shin1, Haengseok Song2
1Department of Biomedical Science & Technology, Konkuk University, Seoul, Republic of Korea.
Abstract:
Two female sex steroid hormones, estrogen and progesterone, are crucial regulators of many physiological functions of reproductive organs. These two hormones are versatile factors linking growth, differentiation, metabolism, and death of cells in the uterus. In recent years, it has become evident that autophagy is involved in the effects of estrogen and progesterone on various cellular events in reproductive organs. Autophagy is the self-eating catabolic process which is linked to cell survival and death in many contexts. In this review, we focus on the new findings concerning the regulation of autophagic response by sex steroid hormones in responsive target organs. We also attempt to further expand our insight into intracellular signaling mediators governing this regulation.
More Related Videos
Related Concept Videos
Regulation of Nuclear Protein Sorting
Target Cell Response to Hormones
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Regulation of Metabolism
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Regulated Protein Degradation
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...

