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Fever of unknown origin in aortic dissection
1The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Putian, 351100, Fujian Province, China. shiminyuan@126.com.
Zeitschrift Fur Rheumatologie
|September 21, 2016
Summary
Aortic dissection can present as fever of unknown origin, not just chest pain. Early diagnosis and treatment are crucial for improving outcomes in these complex thoracic aortic disorder cases.
Area of Science:
- Cardiology
- Vascular Surgery
- Internal Medicine
Background:
- Aortic dissection is a severe complication of thoracic aortic disorders.
- Typical presentation involves acute chest pain, but atypical symptoms like fever of unknown origin can occur.
Purpose of the Study:
- To investigate the characteristics and outcomes of aortic dissection presenting with fever of unknown origin.
- To highlight the importance of considering aortic dissection in patients with unexplained fever.
Main Methods:
- Systematic literature retrieval of 41 articles.
- Analysis of data from 50 patients with aortic dissection and fever.
- Review of clinical presentation, laboratory findings, treatment, and mortality.
Main Results:
- Fever preceded pain in a significant portion of patients.
- Delayed diagnosis and intervention were noted (mean diagnosis time >50 days).
- Elevated white blood cells, cardiac enzymes, and inflammatory markers were observed; infectious-type findings may aid diagnosis.
Conclusions:
- Aortic dissection should be suspected in patients with fever of unknown origin, especially those without chest pain.
- Laboratory findings can provide inflammatory evidence supporting diagnosis.
- Prompt diagnosis and treatment are essential for reducing the 9.5% mortality rate.
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