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Mood disorders and non-celiac gluten sensitivity.
Giovanni Casella1, Roberta Pozzi2, Marta Cigognetti3
1Medical Department, Desio Hospital, Desio, Italy.
Minerva Gastroenterologica E Dietologica
|September 21, 2016
Summary
Non-celiac gluten sensitivity (NCGS) links gluten intake to psychiatric conditions. Research explores the unclear pathogenesis, focusing on gut-microbiota interactions and potential therapeutic targets for neurological and mood disorders.
Area of Science:
- Neurogastroenterology
- Psychiatry
- Immunology
Background:
- Gluten-related disorders are linked to psychiatric conditions.
- Non-celiac gluten sensitivity (NCGS) is diagnosed in gluten-responsive individuals after excluding celiac disease and wheat allergy.
- The neuro-psychiatric mechanisms in NCGS remain unclear.
Purpose of the Study:
- To review the association between gluten and neuropsychiatric disorders.
- To explore the potential role of gut-microbiota interactions in these conditions.
- To identify potential therapeutic strategies targeting gut health.
Main Methods:
- Literature review of studies on gluten, gut microbiota, and central nervous system disorders.
- Analysis of historical and recent research linking gluten sensitivity to mood and neurological conditions.
- Exploration of pathogen-associated factors and intestinal permeability.
Main Results:
- Historical evidence suggests gluten impacts mood in celiac patients.
- Increased anti-gliadin antibodies are observed in bipolar disorder.
- Gut-microbiota dysbiosis is associated with central nervous system disorders like autism, anxiety, and depression.
Conclusions:
- The gut-brain axis and microbiota integrity are crucial in neuropsychiatric disorders.
- Intestinal microbiota modulation presents a potential therapeutic avenue for conditions linked to gluten sensitivity.
- Further research into NCGS pathogenesis is warranted.
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