Related Experiment Video
Updated: Mar 14, 2026
11:38
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
12.8K
A practice analysis of toxicology
Carol S Wood1, Christopher P Weis2, Carla M Caro3
1PO Box 2008, Bldg 1507, MS 6407, Oak Ridge National Laboratory, Oak Ridge, TN 38501, USA.
Regulatory Toxicology and Pharmacology : RTP
|September 21, 2016
Summary
A 2015 practice analysis study by the American Board of Toxicology (ABT) and Society of Toxicology (SOT) updated toxicologist knowledge requirements. This ensures certification exams reflect current toxicology practice and professional standards.
Area of Science:
- Toxicology
- Professional Certification
- Occupational Analysis
Background:
- The American Board of Toxicology (ABT) and Society of Toxicology (SOT) collaborated on a practice analysis in 2015.
- This initiative aimed to ensure the relevance of general toxicology knowledge requirements.
Purpose of the Study:
- To update and validate the knowledge base for professional toxicology certification.
- To align examination content with contemporary toxicological practice.
Main Methods:
- A practice analysis study was conducted involving subject-matter experts.
- An online survey of toxicologists, including ABT Diplomates and SOT members, was utilized.
Main Results:
- A comprehensive profile of domains and tasks in current toxicology practice was established.
- Survey results confirmed the delineated knowledge areas and tasks.
Conclusions:
- The study provides an empirical foundation for ABT's examination and certification requirements.
- Findings will inform the development of test specifications and educational programs for toxicologists.
Related Concept Videos
01:23Toxicity Testing in Animals
98
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
98
01:21Toxicokinetics: Overview
125
Studies that assess how a drug is absorbed, distributed, metabolized, and excreted (ADME) at toxic doses are termed toxicokinetics. Understanding toxicokinetics helps predict adverse drug reactions (ADRs) and manage toxicity in humans.Toxicokinetics differs from pharmacokinetics mainly in the dose levels studied, with toxicokinetics focusing on higher toxic doses. The kinetics at these levels can be non-linear due to altered physiological processes. Toxicodynamics examines the relationship...
125
01:26Toxic Reactions: Overview
3.5K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
3.5K
01:00Drug Toxicity: Overview
123
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
123
01:26Therapeutic Drug Monitoring: Drug Analysis Methods
276
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
276
01:24Drug Toxicity: Dose-Dependent Reactions
100
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
100