Related Experiment Video
Updated: Jul 21, 2026
08:50
Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy
Published on: June 2, 2011
21.4K
Two neutrophilic dermatoses captured simultaneously on histology.
Christina Wlodek1, Nidhi Bhatt2, Cameron Kennedy1
1Department of Dermatology, Bristol Royal Infirmary, Bristol, UK.
Dermatology Practical & Conceptual
|September 21, 2016
Summary
This case study reports a rare instance of Sweet's syndrome and neutrophilic eccrine hidradenitis occurring simultaneously in a patient undergoing chemotherapy for acute myeloid leukemia (AML). This highlights the complex dermatological reactions possible during cancer treatment.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Neutrophilic dermatoses are associated with malignancies and their treatments.
- Concurrent occurrence of distinct neutrophilic dermatoses in a single patient is rare.
- Acute myeloid leukemia (AML) treatment can trigger various cutaneous reactions.
Purpose of the Study:
- To report a rare case of simultaneous Sweet's syndrome and neutrophilic eccrine hidradenitis (NEH).
- To discuss the potential relationship between these neutrophilic dermatoses in the context of AML treatment.
Main Methods:
- A 72-year-old male with AML received chemotherapy (daunorubicin and cytarabine).
- Clinical presentation of pyrexia and disseminated pink plaques was observed.
- Skin biopsy analysis revealed distinct histopathological features of Sweet's syndrome and NEH.
Main Results:
- The patient developed symptoms within 48 hours of chemotherapy initiation.
- Histopathology confirmed dermal interstitial infiltrate consistent with Sweet's syndrome.
- Eccrine gland involvement showed squamous metaplasia and sloughing, consistent with NEH.
Conclusions:
- This is the second reported case of simultaneous Sweet's syndrome and NEH in an AML patient.
- The concurrent presentation is likely an epiphenomenon of the underlying neutrophilic dermatosis.
- Neutrophilic dermatoses can manifest complexly during cancer therapy.
