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Report of mecC-carrying MRSA in domestic swine

Ø Angen1, M Stegger2, J Larsen2

  • 1Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark ysan@ssi.dk.

The Journal of Antimicrobial Chemotherapy
|September 22, 2016
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) carrying mecC was found in Danish swine. This study suggests farm animals and humans on the swine farm transmitted mecC-MRSA locally.

Area of Science:

  • Veterinary Microbiology
  • Zoonotic Diseases
  • Genomic Epidemiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen.
  • The mecC-MRSA strain has been increasingly identified in various animal populations.
  • Understanding the transmission dynamics of mecC-MRSA is crucial for public health.

Purpose of the Study:

  • To investigate the origin and genetic relatedness of mecC-MRSA isolates from a Danish swine farm.
  • To determine the relationship between swine-associated mecC-MRSA and human isolates from the same region.

Main Methods:

  • Whole Genome Sequencing (WGS) was employed to analyze the phylogenetic relationships.
  • Bioinformatics tools were used to examine accessory genome variations.
  • Antibiotic susceptibility profiles were determined through Minimum Inhibitory Concentration (MIC) testing.

Main Results:

  • mecC-MRSA was identified in domestic swine on a Danish farm, but not in cattle.
  • Phylogenetic analysis showed a distinct cluster for swine farm isolates (animals and workers) and a closely related cluster for human isolates from the same municipality.
  • Accessory genome analysis supported the observed phylogenetic relationships.

Conclusions:

  • This is the first report of mecC-MRSA in domestic swine.
  • Evidence strongly suggests transmission of mecC-MRSA between farmers and swine on the farm.
  • The findings indicate localized transmission of mecC-MRSA within the swine farm and the surrounding community.

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