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Updated: Mar 14, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Association of Interleukin-23 Receptor Gene Single Nucleotide Polymorphisms with Ankylosing Spondylitis
Song-Sen Su1, Su-Li Wang2, Liang-Jing Lu2
1Department of Rheumatology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
Objective:
It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population.
Methods:
A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped.
Results:
None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population.
Conclusion:
The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.
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