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The Comparative Toxicogenomics Database: update 2017.

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The Comparative Toxicogenomics Database (CTD) now offers over 30.5 million toxicogenomic connections, including new data on chemical exposures and gene-disease links. This helps researchers understand environmentally influenced diseases.

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Area of Science:

  • Toxicology
  • Genomics
  • Environmental Health Science

Background:

  • The Comparative Toxicogenomics Database (CTD) integrates chemical-gene, chemical-disease, and gene-disease interactions.
  • CTD data is manually curated from scientific literature and integrated with external datasets to predict novel associations.
  • The database currently contains over 30.5 million toxicogenomic connections.

Purpose of the Study:

  • To report updates and advancements in the CTD database.
  • To describe a new exposure module harmonizing exposure science with toxicogenomic data.
  • To introduce a novel dataset of Gene Ontology (GO)-disease inferences.

Main Methods:

  • Manual curation of chemical-gene, chemical-disease, and gene-disease interactions from literature.
  • Integration of core CTD content with select external datasets.
  • Development of a new exposure module and a GO-disease inference dataset.

Main Results:

  • A 33% increase in core CTD data content since 2015.
  • Introduction of a new exposure module linking exposure science with toxicogenomic data.
  • Introduction of a novel dataset of GO-disease inferences identifying shared molecular pathways.

Conclusions:

  • CTD advancements centralize and contextualize chemical exposures with molecular pathways.
  • These updates facilitate hypothesis generation for understanding environmentally influenced diseases.
  • The database supports research into the etiology and mechanisms of diseases influenced by environmental factors.