Electrophysiological Cardiac Modeling: A Review
Mohammadali Beheshti1, Karthikeyan Umapathy1, Sridhar Krishnan2
1Department of Electrical and Computer Engineering, Ryerson University, Toronto, Canada.
Critical Reviews in Biomedical Engineering
|September 23, 2016
Summary
Cardiac electrophysiological models enhance understanding of heart function. Increased computational power enables clinical applications like drug testing and patient-specific treatments, despite validation challenges.
Area of Science:
- Cardiovascular Science
- Computational Biology
- Biophysics
Background:
- Cardiac electrophysiological models have advanced with improved understanding of electrical, mechanical, and chemical processes.
- These models serve as crucial testbeds for hypotheses and conditions difficult to study experimentally.
Purpose of the Study:
- To review studies on cardiac electrophysiological models and their findings.
- To highlight the increasing clinical applicability of these models due to computational advancements.
Main Methods:
- Review of existing literature on cardiac electrophysiological modeling.
- Analysis of findings from studies utilizing these computational models.
Main Results:
- Cardiac models provide insights into electrophysiological phenomena across species.
- Computational complexity remains a challenge, but supercomputing power is enabling clinical use.
- Potential applications include pharmaceutical testing and patient-specific cardiac interventions.
Conclusions:
- Cardiac electrophysiological models are increasingly sophisticated and clinically relevant.
- Advancements in computing power are overcoming previous limitations, paving the way for personalized medicine in cardiology.
