Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
L Kuepfer1, C Niederalt1, T Wendl1
1Bayer Technology Services, Leverkusen, Germany.
CPT: Pharmacometrics & Systems Pharmacology
|September 23, 2016
Summary
This tutorial explains physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling, demonstrating practical PBPK model building. It simulates ciprofloxacin
Area of Science:
- Pharmacology and Pharmaceutical Sciences
- Computational Biology
- Drug Development
Background:
- Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling is crucial for understanding drug behavior.
- Practical application of PBPK/PD models requires a structured workflow.
Purpose of the Study:
- To introduce fundamental concepts of PBPK/PD modeling.
- To demonstrate the practical implementation of PBPK model building.
- To simulate the antibacterial activity of ciprofloxacin.
Main Methods:
- Construction of a PBPK model for ciprofloxacin.
- Coupling the PBPK model with a pharmacodynamic (PD) model.
- Simulation of antibacterial activity.
Main Results:
- The tutorial illustrates a typical PBPK model building workflow.
- The coupled PBPK/PD model successfully simulates ciprofloxacin's antibacterial activity.
Conclusions:
- PBPK/PD modeling provides a framework for understanding drug disposition and effects.
- Practical implementation of PBPK/PD models aids in drug efficacy prediction.
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