Related Experiment Video
Updated: Mar 14, 2026
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
Published on: May 20, 2024
Chitinase expression in Alzheimer's disease and non-demented brains regions
C Sanfilippo1, L Malaguarnera2, M Di Rosa2
1Section of Neurosciences, Department G.F. Ingrassia, University of Catania, Via Santa Sofia, 78, 95123 Catania, Italy.
Background:
Alzheimer disease is the most typical form of dementia. The causes of AD are not yet completely understood, but they include a combination of genetic, environmental and lifestyle factors that influence ja person's risk for developing the disease. New biomarkers related to these processes could be important for the diagnosis and follow-up of AD patients.
Objective:
The intent of this study was to weigh the expression levels of chitinases genes in brain regions of late-onset AD (LOAD) patients.
Materials And Methods:
We analysed three microarray datasets obtained from the NCBI in order to verify the expression levels of chitinase genes family in brain biopsies (CR, DLPFC and VC) of LOAD patients compared to healthy subjects. We also divided the sample in function of sex difference and ages.
Results:
The analysis showed that all chitinases genes were modulated in LOAD brain regions compared to healthy subjects. Furthermore positively correlation was identified between chitinases gene expression and healthy age's subjects. Moreover, it has been shown that CHI3L1 and CHI3L2 were regulated differently in healthy and LOAD brain depending on the sex.
Conclusion:
It is possible to conclude that all chitinases could be considered new potential markers for LOAD disease.
