Related Experiment Video
Updated: Mar 14, 2026
14:14
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
Published on: December 6, 2014
17.4K
Clinical and imaging considerations in primary immunodeficiency disorders: an update
Eveline Y Wu1, Lauren Ehrlich2, Brian Handly3
1Department of Pediatrics, University of North Carolina at Chapel Hill, 030 MacNider Hall, CB#7231, Chapel Hill, NC, 27599, USA. eveline.wu@unc.edu.
Pediatric Radiology
|September 23, 2016
Summary
Primary immunodeficiencies (PIDs) are genetic disorders with varied symptoms. Radiologists play a key role in early PID diagnosis and managing complications through diagnostic imaging.
Area of Science:
- Immunology
- Radiology
- Genetics
Background:
- Primary immunodeficiencies (PIDs) encompass a diverse group of inherited disorders.
- These conditions manifest with a wide spectrum of clinical presentations.
- Early recognition and management are crucial for patient outcomes.
Purpose of the Study:
- To provide a concise overview of select primary immunodeficiency diseases.
- To highlight the critical role of radiologists in the early diagnosis of PIDs.
- To emphasize the importance of diagnostic imaging in PID management.
Main Methods:
- Review of select primary immunodeficiency disorders.
- Discussion of the radiologist's contribution to diagnosis and surveillance.
- Emphasis on the utility of diagnostic imaging techniques.
Main Results:
- Radiologists can significantly aid in the early detection of PIDs.
- Diagnostic imaging is essential for identifying and monitoring PID complications.
- Informed imaging interpretation is vital for comprehensive PID care.
Conclusions:
- Radiology is indispensable for the diagnosis, surveillance, and management of PIDs.
- Early and accurate imaging interpretation facilitates timely intervention.
- A collaborative approach involving radiologists improves patient outcomes in PIDs.
Related Concept Videos
01:25Immunodeficiency Diseases
2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.7K
01:16Primary Lymphoid Organs
16.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.4K
01:22Development of Immunocompetence
1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
01:15Secondary Lymphoid Organs
10.0K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.0K
01:27Disorders of Leukocytes
2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
01:20Special Features of Adaptive Immunity
3.9K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.9K