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Updated: Jul 30, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
[Homeostasis of the auto-oscillation period in a model of a cellular circadian clock]
Abstract:
A mathematical model was numerically investigated which describes the autooscillatory temporal organization of futile cycles of the carbohydrate branch of energy metabolism. Using an optimization method we found a region in the parametric space of the model in which the circadian oscillation period was practically constant, although the major eight parameters varied in a wide range. Such homeostasis of the period is due to synergistic effects of the four feed-back mechanisms regulating activities of the key enzymes. The result obtained supports the metabolic theory of the circadian cell clock.
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