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Updated: Mar 14, 2026
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
[Assessment of a brief fatigue inventory in patients with hematologic malignancies]
Luz Alejandra Lorca1, Cinara Sacomori2, Bárbara Puga1
1Unidad de Hematología Intensiva y trasplante de progenitores hematopoyéticos, Hospital del Salvador, Servicio de Salud Metropolitano Oriente, Santiago, Chile.
Background:
Fatigue is one of the most common and distressing symptoms experienced by cancer patients.
Aim:
To validate the Brief Fatigue Inventory in people treated for hematological neoplasms.
Material And Methods:
In a cross-sectional study, the Brief Fatigue Inventory was answered by 122 patients aged 40 ± 14 years (50% women) treated for hematological neoplasms at an intensive hematological unit of a public hospital between July 2010 and July 2013. Socio-demographic and clinical parameters were obtained from their clinical records.
Results:
Fatigue was present in nearly all patients (99.2%) in minor (50%), moderate (36.9%) or severe (12.3%) levels. The average fatigue score was 4.5 ± 1.9). The Brief Fatigue Inventory had a good internal consistency (Cronbachs alpha = 0.973) and proved to be one-dimensional (84.3% of the explained variance). Women reported that fatigue interfered more with enjoy-ment of life than men (p = 0.036).
Conclusions:
The Brief Fatigue Inventory is a reliable instrument that can be used in clinical practice. It allows a quick assessment of the level of fatigue. People treated for hematologic cancer have a high prevalence of fatigue.
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