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Updated: Mar 14, 2026
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Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
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Effects of Testosterone Therapy on Cognitive Function in Aging: A Systematic Review
Jeremy T Hua1, Kerry L Hildreth, Victoria S Pelak
1Departments of *Neurology †Medicine ‡Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.
Summary
Testosterone supplementation may improve cognitive function in aging men, but results vary. More standardized studies are needed to confirm benefits for elderly men, especially with rising use.
Area of Science:
- Endocrinology
- Neuroscience
- Gerontology
Background:
- Aging men experience changes in endogenous testosterone levels.
- Testosterone influences various cognitive domains, including memory and executive function.
- Testosterone supplementation is increasingly used in clinical practice for aging men.
Purpose of the Study:
- To review existing studies on testosterone supplementation and cognitive function in aging men.
- To identify cognitive measures and outcomes in current research.
- To highlight variability in study results and methodological inconsistencies.
Main Methods:
- Systematic review of randomized controlled studies.
- Analysis of cognitive domains assessed (verbal fluency, visuospatial abilities, memory, executive function).
- Examination of testosterone measurement and supplementation protocols.
Main Results:
- Promising associations found between testosterone supplementation and cognitive improvements.
- Results varied across studies, with some showing benefits in eugonadal men and those with low testosterone.
- Inconsistent methods for testosterone assessment and cognitive testing contribute to outcome variability.
Conclusions:
- Testosterone supplementation shows potential for cognitive enhancement in aging men.
- Further research with larger sample sizes and standardized methodologies is crucial.
- Understanding sustained benefits requires addressing current inconsistencies in testosterone and cognitive assessments.
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